On the other hand, SUCLG2 and SLC25A24 were not significantly down-regulated as HIGD1A in adenoma and five subtypes of CRC, while SUCLG2 exhibited consistently decreased expression in both two independent studies of rectal mucinous adenocarcinoma, and SLC25A24 also showed down-regulation in one out of two independent studies (Fig. 5e). This evidence concerns the gene HIGD1A and rectum mucinous adenocarcinoma.