Our results showed that Spike IFN-γ, Spike IP-10, Spike IL-2; NP Pool1 RANTES; NP Pool2 IP-10 and ORF3a IL-2 are the most important in vitro conditions to distinguish COVID-19- from NO-COVID-19-subjects over all the antigen stimulations. Here, CXCL10 is linked to COVID-19.