The results showed 5 common KEGG pathways in the N-CIN group (p < 0.01), namely, DNA mismatch repair (PCNA [20], EXO1 [21], POLD1, MSH6, and LIG1), the cell cycle (MCM3, MCM5 [22], CDC6, MCM6 [23], CHEK2, PKMYT1, CDC7, RBL1, WEE1, CCNA2 [24], and TTK), DNA replication (PCNA, POLD1, DNA2, MCM3, MCM5, PRIM2, POLE2, MCM6, LIG1, RNAEH2A, and PRIM1), cysteine and methionine metabolism (LDHC), and nucleoside exception repair (PCNA, POLD1, POLE2, and LIG1). This evidence concerns the gene PRIM1 and cervical squamous intraepithelial neoplasia.