Accordingly, we examined the levels of CCL3 and CCL4 in the supernatants of JeKo-1, Mino and primary MCL cells treated with or without BTKi individually for 48 h in the presence of anti-human IgM F (ab)2, and the results indicated that these three BTKi significantly suppressed the production of CCL3 and CCL4 with similar degree in MCL cells (Fig. 3c). Here, CD40LG is linked to mantle cell lymphoma.