Accordingly, we examined the levels of CCL3 and CCL4 in the supernatants of JeKo-1, Mino and primary MCL cells treated with or without BTKi individually for 48 h in the presence of anti-human IgM F (ab)2, and the results indicated that these three BTKi significantly suppressed the production of CCL3 and CCL4 with similar degree in MCL cells (Fig. 3c). The gene discussed is CCL3; the disease is mantle cell lymphoma.