TNF and cancer: In addition, today, abnormalities in oxidant and antioxidant systems, growth factors, adrenomedullin (ADM), inflammatory cytokines (interleukin-1beta (IL-1β)), various interleukins (IL-6, IL-15, IL-17, and IL-18), tumor necrosis factor-alpha (TNF-α), and chemokines are considered to contribute to the pathogenesis of DM-related disorders, inflammatory diseases, and cancers by activating various transcription factors [4–7].