Half of the patients receiving IV diuretics and more than a third who had CHF as a diagnosis at discharge belonged to the top quartile of bio-ADM concentrations (IV diuretics: 6%, 21%, 35%, and 50% and CHF at discharge: 4%, 11%, 24% and 35% of each bio-ADM quartile in ascending order). The gene discussed is ADM; the disease is congestive heart failure.