p300/CBP‐associated factor (PCAF) is a member of the GCN5‐related protein acetyltransferase N‐acetyltransferase family with histone acetyltransferase activity, which exhibits ambiguous or controversial functions in tumorigenesis18, 21 However, whether the PCAF–ISX–BRD4 mechanism is restricted to non‐small‐cell lung cancer (NSCLC) or it is also active in other tumor entities during malignant transformation remains unclear. Here, ISX is linked to neoplasm.