RIPK3 and gastric cancer: While the disrupted turnover of parietal cells under pathological conditions such as chronic H. pylori infection might result in an excessive parietal cell loss, which is a well-known glandular atrophic process and gastric cancer precursor, will significantly increase the risk for gastric cancer, Wang et al. have found that a high positive rate of RIPK3 in different types of gastric cells including the mucosal epithelial cells, smooth muscle cells and fibroblasts, while a negative for glandular epithelium in the stomach of mice (Wang et al. 2016).