SLC5A5 and cancer: We have previously demonstrated that whole-body medical imaging technologies such as single-photon emission computed tomography (SPECT) or positron emission tomography (PET) in combination with reporter gene technology and appropriate imaging probes enabled quantitative in vivo tracking of murine cancer and its metastasis.24–27 Therefore, we employed the sodium iodide symporter (NIS) as a radionuclide reporter.