Specifically, the susceptibility to ferroptosis inducers in some human cancer cell lines is reduced by suppression of acyl-CoA synthase 4, which synthesizes long-chain polyunsaturated CoAs with a preference for arachidonic acid (C20:4 n-6), or of lysophosphatidylcholine acyltransferase 3, which remodels PLs via the reacylation (Lands) cycle. Here, LPCAT3 is linked to cancer.