SLC16A3 and cancer: To this end, MCTs play important roles, and MCT1 and MCT4 have been shown to be overexpressed in a number of cancers, including glioblastoma, colon cancer, breast cancer, prostate cancer, clear cell renal cell carcinoma, oesophageal squamous carcinoma pancreatic cancer and non-small cell lung carcinoma (NSCLC)13–15,22.