SLC16A3 and non-small cell lung carcinoma: To date, 8 out of 9 NSCLC tissues with predicted pathogenic ND mutations contained strongly MCT4-positive cancer cells (IHC score > 3 +), while only 1 out of 8 tissues without pathogenic ND mutations contained strongly positive cells (P < 0.05, χ2 test with Yates’ correction) (Table 2).