TREM2 activation inhibits microglia-mediated neuroinflammation and apoptotic neuron phagocytosis29,30 and has been reported to be expressed in neurological diseases, such as traumatic brain injury, cerebral ischaemia, amyotrophic lateral sclerosis, Alzheimer's disease (AD) and PD31,32. This evidence concerns the gene TREM2 and amyotrophic lateral sclerosis.