Continuosly reported high levels of inflammatory cytokines and infiltration of tissues with granuloctes and monocytes as demonstrated for lung tissue in autopsy using caspase-3 immunostaining probably also play an important role in the pathogenesis of coagulopathy and thrombophilia in COVID-1937,42 with a particular impact on endothelial damage. This evidence concerns the gene CASP3 and thrombophilia.