MCM2 and prostate adenocarcinoma: Elevated gene expression levels of MCM2/3/4/6 were also observed in NCI-H660, a NEPC cell line, when compared to prostate adenocarcinoma cell lines and two CRPC cell lines, 22Rv1 and DU145, showed slight up-regulation of MCM2/3/4/6 genes compared with LNCaP, VCaP, and PC-3 cell lines17 (Fig. 1B).