These results further confirmed that the 29940 G-to-C mutation in the NLRP3 3′-UTR suppressed NLRP3 expression and downstream inflammatory cytokine production by binding with miR-146a in a gain-of-function manner, which ultimately protected patients against susceptibility to sepsis progression and exhibited potentially important diagnostic and therapeutic value (Fig. 7). The gene discussed is NLRP3; the disease is Sepsis.