Approximately 60 genetic variants within the entire NLRP3 gene have been identified so far, among which rs10754558 (29940G>C), rs35829419 (Q705K), rs10925019, rs4925648 and rs4612666 have been well studied in association with susceptibility to ulcerative colitis, Alzheimer's disease, Crohn's disease and acne vulgaris18–21. The gene discussed is NLRP3; the disease is ulcerative colitis.