The 29940 G>C genetic variation in the 3′-UTR of NLRP3 attenuated the stability and expression of NLRP3 mRNA in a gain-of-function manner, which resulted in susceptibility to several inflammation-related disorders, such as asthma, ischemic stroke and rheumatoid arthritis22,37,38. This evidence concerns the gene NLRP3 and ischemic stroke.