Recent studies using overexpressing TREM2/DAP12 cell lines indicate that pSYK signalling induced by PS is compromised in R47H TREM2 lines7,13, however pSYK signalling downstream of PS-TREM2 interactions has so far been unexplored in microglial models of TREM2 AD variants. The gene discussed is TREM2; the disease is Alzheimer disease.