STING1 and cancer: Recently, specific efflux and/or influx channels for 2′3′cGAMP have been identified for monocytes, macrophages, fibroblasts and endothelial cells.47–51 As STING activation within host immune cells is key for anti-cancer responses, expression of these channels within cancers may drastically alter the nature of STING responses in response to either endogenous or exogeneous STING activation.