IRF5 and familial pancreatic carcinoma: Indeed, MYC complexes bind directly to IRF5, IRF7, STAT1 and STAT2 in pancreatic cancer, repressing interferon responses.40 MYC may have a dual role in cancer progression, promoting both chromosomal instability and direct or indirect suppression of STING-mediated immune responses, resulting in an immunosuppressed microenvironment.