Interestingly, a recent report identifies suppression of STING signaling via mutant p53 binding and inhibition of TBK1 downstream of STING in breast cancer cells, suggesting that STING-mediated interferon responses may be prevented in p53 mutant cancer cells via this mechanism.32 In contrast, higher rates of mutation in PI3K and MAPK1 were observed in pnSTINGhigh signature cases. Here, PIK3CA is linked to breast cancer.