Moreover, cGAS-STING pathway activation within fibroblasts can promote resistance to oncolytic viral therapy, with sensitivity restored by TBK1 inhibition, suggesting STING signaling within fibroblasts may indeed promote tumor progression.52 Further exploration of this may address the unexpecting finding of a disconnection between STING and interferon responses in ER- disease. This evidence concerns the gene TBK1 and neoplasm.