Another member of the cyclin family, Cyclin E1, is amplified in triple negative breast cancers which have high levels of replicative stress, in keeping with the findings of genomic instability in this poor prognosis ER + breast cancer subgroup.44 In addition, the finding of increased mTOR activity in the pnSTINGlow subgroup may suggest an alternative therapeutic approach. The gene discussed is CCNE1; the disease is triple-negative breast carcinoma.