Interestingly MYC has recently been reported to suppress STING signaling in TP53- and BRCA1-mutant breast cancer.39 This supports the hypothesis that amplification of MYC is a mechanism of STING repression (and subsequent immunosuppression) in pnSTINGlow tumors, potentially targetable using novel MYC inhibitors. The gene discussed is TP53; the disease is breast carcinoma.