Besides the cytokines like IL6 and IL8, that exert wide spectrum effect on the biological behavior of tumor cells, we found that disrupting SEs by BET inhibitors inhibited a set of cancer stemness genes, including TP63, MET, FOSL1, and YAP1. TP63 is an isoform of the p63 family and plays an important role in the maintenance of the epithelial stem repertoire. Here, TP63 is linked to cancer.