We previously reported the use of oligopyridylamide-based α-helix mimetics to effectively modulate self-assembly of the amyloid-β peptide (Aβ)20,21 and islet amyloid polypeptide (IAPP)22,23, which are associated with Alzheimer’s disease (AD) and type II diabetes (T2D), respectively. The gene discussed is IAPP; the disease is Alzheimer disease.