Evidence that these effects are due to direct intracellular target engagement comes from the following experiments: (i) confocal microscopy, where extensive colocalization of fluorescently labeled ADH-6 with antibody-stained intracellular mutant p53 was observed; and (ii) CETSA, which demonstrated strong stabilization of p53 mutants in cancer cells by ADH-6 (Fig. 3 and Supplementary Fig. 10). The gene discussed is TP53; the disease is cancer.