Subsequent studies in human pancreatic carcinoma MIA PaCa-2 cells harboring mutant R248W p53 (Fig. 3 and Supplementary Figs. 7 and 9), and N. benthamiana cells transfected with YFP-tagged WT and R248W p53 DBDs (Supplementary Fig. 8), showed that ADH-6 effectively dissociates intracellular mutant p53 amyloid-like aggregates. Here, ADH6 is linked to exocrine pancreatic carcinoma.