CDKN1A and cancer: ChIP-qPCR analysis revealed that ADH-6 treatment resulted in recruitment of mutant p53 to the WT protein’s primary transcriptional targets, such as Cdkn1a, PIG3, and NOXA (Supplementary Fig. 14 and Supplementary Table 1), that are not only key mediators of p53-dependent cell cycle arrest and apoptosis87–91, but also determinants of the cytotoxic response of cancer cells to standard chemotherapy and targeted cancer therapy92,93.