Conversely, increased CDK6 significantly associated with decreased OS in mUC (HR: 1.87, p < 0.01) and showed a trend toward lower OS in NSCLC (HR = 1.40, p = 0.23), and lower PFS in RCC (HR = 1.2, p = 0.5). The gene discussed is CDK6; the disease is renal cell carcinoma.