In a cell-based study, the introduction of myr-Akt or shPten into primary murine endometrial cells, followed by co-transplantation with the uterine stroma from neonatal WT mice, resulted in the development of adenocarcinoma in the kidney capsule [35], suggesting the importance of the microenvironment of the uterine stroma in EC development. This evidence concerns the gene AKT1 and adenocarcinoma.