The specific distributions of CD8+ T cells and CD163+ macrophages in breast cancer (184), cytotoxic T cells (CTLs) and memory T cells in colorectal cancer (185), CD8+ T cells and Tregs in NSCLC (186), and CTLs in primary melanoma (81) residing in different compartments were found to be significantly related to clinical outcomes, improving our knowledge of a precise diagnosis. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.