In the current study, we found that glioma cell lines that have either homozygous (D423) or heterozygous (D502, U343) deletions of ENO1 are selectively more sensitive to the enolase inhibitor POMHEX than are ENO1 rescued (D423 ENO1) and wild-type cells (LN319) (Fig. 1 a-c). This evidence concerns the gene ENO1 and central nervous system cancer.