MKI67 and neoplasm: Although the association between a high MIB-1-expression and likelihood of local tumor recurrence needs to be interpreted with caution, we hypothesize that a high MIB-1-index might indicate a more aggressive tumor biology with a higher probability for tumor relapse, warranting a more offensive treatment approach as well as a more frequent and longer follow-up in patients exhibiting a high MIB-1 index.