Unlike individuals with APOE Ɛ2, individuals with APOE Ɛ4 have lower plasma concentration of APOE and C-reactive protein (CRP), along with higher plasma levels of cholesterol, LDL-C, APOB, lipoprotein (a), atherosclerosis, and BMI, and are at a higher risk of CVD. The gene discussed is CRP; the disease is atherosclerosis.