IL1B and rheumatoid arthritis: Likewise, IL-1β-induced HFLS-RA treated with ACRH, QRF, and BQ at their respective concentrations (0.05, 0.5, and 5 μg/mL) showed significant (P < 0.05) reductions/inhibitions of invaded cells (ACRH: 43.56 ± 1.79%, 26.13 ± 4.64%, and 0.0 ± 0.0%; QRF: 39.44 ± 8.09%, 32.17 ± 5.80%, and 0.0 ± 0.0%; and BQ: 50.84 ± 8.65%, 32.39 ± 1.84%, and 0.0 ± 0.0%), compared to negative control (100 ± 0.0%) (Fig. 4b), after 22 h incubation.