VEGFA and rheumatoid arthritis: While the previous work [33, 42] highlighted the anti-angiogenic effect of the samples (ACRH and BQ) in the physiological condition of HUVECs angiogenesis, our present data, particularly on QRF, demonstrated their inhibitory activities against the pathological state of HUVECs angiogenesis stimulated via excessive VEGF, mimicking the RA angiogenesis.