TNF and rheumatoid arthritis: Contrarily, in another study, Umar et al. [67] reported the non-marked effect of thymoquinone in TNF-α-induced HFLS-RA viability, yet the compound was able to inhibit cell adhesion via regulation of apoptosis-regulated signaling kinase 1 (ASK1), indicating its anti-angiogenic effect was not mediated via inflammatory (NF-κB) pathway.