Using univariable analysis, size <50 mm (OR: 4.500, 95% CI: 1.174–17.249, P = 0.028), ER- (OR: 3.596, 95% CI: 1.398–9.246, P = 0.008), PgR- (OR: 3.595, 95% CI: 1.398–9.246, P = 0.008) and HER2 (OR: 3.788, 95% CI: 1.410–10.179, P = 0.008) predicted those likely to downstage in the breast, while PgR-independently predicted tumour downstaging following multivariable analysis (OR: 3.590, 95% CI: 1.465–8.797, P = 0.005) (Table 6). Here, ERBB2 is linked to neoplasm.