Third, although NT-proBNP is a well-established predictor of future CV risk in general populations with and without CVD, with high sensitivity and specificity and strong positive predictive values [13,14,44], none of the studied patients had clinical HF and the lack of specific test of cardiac function (e.g., echocardiography) can be considered as a limitation. The gene discussed is NPPB; the disease is hydrops fetalis.