BAX and osteosarcoma: The results showed Bax and Caspase3 degradation were reduced by CQ, indicating that Bax and Caspase3 induction was partly the result of the inhibition of protein turnover by CQ after treatment with cycloheximide which inhibits the protein synthesis in osteosarcoma cells (Figure 6A–6C); and CQ induced apoptosis is related to lysosomal inhibition, or at least as a cause, in OS cells (Figure 6D).