Indeed, the upregulation of stem cell markers upon functional BAP1 depletion is seen in human uveal melanoma and renal cell carcinoma, and is associated with aggressive cancer behaviour and poor patient outcome (Matatall et al., 2013; Peña-Llopis et al., 2012; Harbour et al., 2010). The gene discussed is BAP1; the disease is hereditary clear cell renal cell carcinoma.