However, results from previous studies of cancers that are strongly associated with an EMT process during metastatic transformation such as uveal melanoma, clear-cell renal cell carcinoma, gastric adenocarcinoma, colorectal cancer, and non-small-cell lung cancer showed a significant decrease in tumour BAP1 expression and worse clinical outcomes (Kalirai et al., 2014; Yan et al., 2016; Tang et al., 2013; Fan et al., 2012). This evidence concerns the gene BAP1 and colorectal cancer.