In an analysis by Geng et al. [2] of electronic health records (between 1985 and 2013) from over 5000 adults with baseline CKD stage G3–G4 (mean follow-up of 23 ± 10 years), PTH was found to be an independent predictor of fracture, vascular events, and death (Fig. 1). The gene discussed is PTH; the disease is chronic kidney disease.