While there has been much interest to explore the therapeutic potential of nutritional vitamin D, a recent meta-analysis of randomised controlled trials suggests that nutritional vitamin D supplements in non-dialysis CKD do not reliably and consistently lower PTH even at higher doses, and the average 25(OH)D levels in treated patients do not reach > 50 ng/mL in the majority of randomised controlled trials, implying a limited potential of nutritional vitamin D to reach the 25(OH)D levels suggested as needed to effectively control SHPT [17]. Here, PTH is linked to chronic kidney disease.