The risk of DTC in carriers of a germline DICER1 pathogenic variant might be secondary to the greatly increased prevalence of benign thyroid nodules, although, given the low number of reported patients with DICER1-associated thyroid cancer, it has been suggested that only a small percentage of benign thyroid nodules progress to thyroid cancer [5, 12, 24]. This evidence concerns the gene DICER1 and thyroid gland carcinoma.