CN is one of the most common DICER1-associated tumors (estimated cumulative incidence among carriers of a germline DICER1 pathogenic variant [index and non-index case patients] is ~ 7% by the age of 6 years), whereas malignant diseases as Wilms tumors and anaplastic sarcoma are very rare [12]. This evidence concerns the gene DICER1 and cyclic hematopoiesis.