Concerning PD-L1 antibody clone 22C3, TILs > 5% and MMR deficiency were the only two clinicopathological features that were significantly associated with PD-L1 positivity in all three measures (overall, TPS, and IC; p values < 0.001 each for TILs > 5% and MMR deficiency). Here, CD274 is linked to mismatch repair cancer syndrome 1.