SLC17A6 and Peripheral demyelination: Using EM, confocal microscopy, and electrophysiology in the hippocampus of the cuprizone model of demyelination, we showed that C1q was selectively enriched at vGLUT2+ and vGAT+ puncta, which were engulfed by microglial processes resulting in a substantial reduction in the number of only GABAergic synaptic puncta in the stratum pyramidale and oriens of CA2 and loss in GABAergic inhibition.