Our findings of a disrupted inhibitory CA2 circuit related to impaired memory for conspecifics in the demyelinated hippocampus resemble the changes in CA2 seen when deleting the psychiatric-disease related gene 22q11.2 causing also an impaired CA3 to CA2 feedforward mediated inhibition as well as a reduced CA2 PN spike output resulting in an impaired social memory [62]. Here, CA2 is linked to glycogen storage disease VI.