The C3d staining showed little co-localization with vGAT+ puncta (Fig. 4h) or other synaptic markers (Supplementary Fig. 5, online resources) and the extent of colocalization it did not vary between cuprizone and control mice (Fig. 4i) but it showed extensive co-localization with GFAP+ astrocytes (Fig. 4j), likely reflecting the neurotoxic A1 type of astrocytes previously described in MS tissue [45]. Here, GFAP is linked to myeloid sarcoma.