Adding PICP, Gal-3 and their interaction on top of the clinical and biological model (i.e., age, history of CV disease, diabetes mellitus, sex, dialysis vintage, body mass index, systolic blood pressure, albumin and log hs-CRP at baseline) resulted in significant NRI for CV death and all-cause mortality [NRI = 0.080 (0.019–0.143) and 0.085 (0.029–0.129), respectively]. This evidence concerns the gene LGALS3 and diabetes mellitus.