Examples includethioredoxin-reductase and citrate synthase that have been previouslyshown to be upregulated in Alzheimer’s disease brains25 and in an 8-month-old transgenic mouse modelof Alzheimer’s disease,26 respectively.These two mitochondrial proteins among several others were downregulatedin the hippocampus of the study group, which could be a sign of analtered mitochondrial function resulting from enhanced degradationof Aβ42 by SST-scFv8D3. The gene discussed is CS; the disease is early-onset autosomal dominant Alzheimer disease.