SST and early-onset autosomal dominant Alzheimer disease: Using LC–MS, we furtherevaluated the anti-Alzheimer’s disease effects of SST-scFv8D3.Following a triple intravenous injection of SST-scFv8D3, the LC–MSanalysis of the brain proteome revealed that the majority of downregulatedproteins consisted of mitochondrial proteins regulating fatty acidoxidation, which are otherwise upregulated in APPswe mice comparedto wild-type mice.