DNM1 and early-onset autosomal dominant Alzheimer disease: This protein is extensively studiedin Alzheimer’s disease, where it has been demonstrated to beinvolved in regulating Aβ formation and aiding its aggregation.47,48 Moreover, APPswe mice with neprilysin knockout displayed a significantincrease in dynamin-1 levels.49 Whethersuch an unexpected increase is mediated by our Aβ degradingSST-scFv8D3 protein drug or it is secondary to other interaction partnersof SST needs to be further investigated.