Synaptic dysfunction is one of the main pathologicalevents in Alzheimer’s disease, where the interaction betweenAβ and syntaxin-1A has been demonstrated as a major contributingfactor.16 The levels of the latter proteinwere increased in the hippocampal area of APPswe after treatment withSST-scFv8D3 measured with LC–MS (adjusted p-value 0.007) (Table S3). Here, STX1A is linked to early-onset autosomal dominant Alzheimer disease.