ATXN1 and early-onset autosomal dominant Alzheimer disease: The latter protein has recentlybeen suggested to be related to Alzheimer’s disease, as Aβaccumulation and neuronal degeneration were observed in the hippocampuswhen ataxin-1 is knocked out in a transgenic mouse model of Alzheimer’sdisease.42 Serine/threonine protein phosphatase2A (gamma and epsilon isoforms) was also among the upregulated proteinsin the treatment group.