APP and early-onset autosomal dominant Alzheimer disease: Familial mutations in APP, such asthe Swedish mutation (APPswe) (KM670/671NL), increase Aβ productionand lead to early onset of Alzheimer’s disease.2 Accumulation of Aβ can also be attributed to thedecline in the activity and/or levels of the Aβ-degrading enzymes,including neprilysin.3