APLP-1is a member of the amyloid precursor family and is highly homologousto APP, showing similar enzymatic digestion processing into shortAβ-like peptides that accumulate in Alzheimer’s diseasebrains.31,32 Moreover, APLP-1 has been suggested as acerebrospinal fluid (CSF) biomarker in Alzheimer’s disease.33 Decreased levels of this protein in the hippocampalarea might further support the anti-Alzheimer’s effects ofSST-scFv8D3. This evidence concerns the gene APLP1 and early-onset autosomal dominant Alzheimer disease.