The first reported trifunctional molecules exhibited acetylcholinesterase (AChE) inhibitory activity together with the reduction of AChE‐induced amyloid‐β aggregation and metal chelating properties.[17] Other discoveries have found molecules that tackle relevant AD targets such as AChE and its induced β‐amyloid aggregation, butyrylcholinesterase, monoamine oxidase or metal chelation.[18, 19, 20]. This evidence concerns the gene ACHE and Alzheimer disease.