Other possible disadvantages of the use of propofol in COVID-19 patients include the occurrence of hyperlipidemia, which has been associated with an increased risk of mechanical failure of the extracorporeal circuit [15, 39], as well as an increased expression of angiotensin-converting enzyme 2 (ACE-2) in human pulmonary vessels [40]. This evidence concerns the gene ACE2 and hyperlipidemia.