DRC1 and male infertility: Herein, we identified twohomozygous DRC1 variants in human patients that were associated withmultiple morphological abnormalities of the sperm flagella (MMAF) and male infertility.Drc1−/−, Drc1R554X/R554X andDrc1W244X/W244X mice on the C57BL/6 background suffered frompre-pubertal mortality.