This very much resembles the concept of the agonistic action of pioglitazone (an FDA-approved synthetic PPAR-γ agonist and antidiabetic drug) to activate PPAR-γ which was already proven to be effective in controlling inflammatory responses in other chronic inflammatory diseases such as multiple sclerosis and systemic lupus erythematosus (60, 61). Here, PPARG is linked to multiple sclerosis.