Multivariate Cox analysis adjusted for clinicopathological confounding factors such as SBP, diastolic blood pressure (DBP), serum albumin, e-GFR, cholesterol, proteinuria, u-RBC, anemia and pathological changes (MESTC), strongly illustrated that serum bilirubin was an independent protective factor of prognosis in both unmatched cohort (HR = 0.17, 95% CI, 0.03–0.99; P < 0.05) and matched cohort (HR = 0.05, 95% CI, 0.00–1.03; P = 0.050) (Table 3). The gene discussed is ALB; the disease is anemia.