MAPK, the mitogen-activated protein kinases, is a group of evolutionarily conserved serine/threonine protein kinases that are activated by a series of extracellular signals and regulate many physiological activities, such as inflammation, apoptosis, carcinogenesis, tumor cell invasion, and metastasis (Chauhan et al., 1997; Han et al., 1997; Vo et al., 1998; Regalo et al., 2010). This evidence concerns the gene WNK2 and neoplasm.