Interestingly, NLRP1, SELE, TRPV1, and CSF1R can all signal through the cytokine interleukin 1B, which is linked with cardiovascular disease, apoptosis and inflammation (Ley, 2003; Musumeci et al., 2011; Wei et al., 2015; Chowdhury et al., 2017; Wang et al., 2017; Figure 2). This evidence concerns the gene SELE and cardiovascular disorder.