In the context of cardiovascular disease, TRPV1 is rather protective against atherosclerotic plaque formation by reducing lipid storage and diminishing endothelial cell inflammation but also has proapoptotic characteristics (Sappington et al., 2009; Ma et al., 2011; Zwicker et al., 2015; Bleda et al., 2017). The gene discussed is TRPV1; the disease is cardiovascular disorder.