Previous studies have demonstrated that TDP-43 ALS-linked mutations, which include the ones we have studied here, are more stable than WT TDP-43 having enhanced interactions with other RNA-binding proteins such as FUS (Ling et al., 2010), another ALS-associated protein also found within insoluble cytoplasmic inclusions (Baron et al., 2013; Sama et al., 2013; Lenzi et al., 2015). Here, TARDBP is linked to amyotrophic lateral sclerosis.