AKT1 and chlamydia trachomatis infectious disease: In addition, the PI3K/Akt signaling pathway is involved in chlamydial infection, including invasion (Lane et al., 2008; Patel et al., 2014; Subbarayal et al., 2015), resistance to apoptosis (Rajalingam et al., 2008; Zou et al., 2018), and stress response (Thapa et al., 2020).