As shown in Figures 1D, E, the overexpression of miR-27-3p decreased the expression of PSEN-1 but not that of PSEN-1 with a mutated miR-27-3p binding site (PSEN-1Mut) in the cytoplasm or the accumulation of NICD in the nucleus of HCC-1937 (Figure 1D) and MDA-MB-436 (Figure 1E) TNBC cells. This evidence concerns the gene PSEN1 and hepatocellular carcinoma.