Next, we analyzed the gene expression of PHLPP in NSCLC cell line according to gefitinib sensitivity from the database of GSE4342 (18), PHLPP mRNA expression was higher in the gefitinib-sensitive group (IC50 <0.5μM) compared to the gefitinib-resistant group (IC50≥0.5μM), the mean value of mRNA expressions were 6.5± 0.35 and 5.9 ± 0.15 (Figure 1E). This evidence concerns the gene PHLPP1 and non-small cell lung carcinoma.