In 23 pretreatment and post-relapse tumor sections, we detected 10 of 23 (43.5%) patients with T790M mutation (Figure 6A), 18 of 23 (78.3%) patients showed decreased PHLPP expression at the time of the radiographical progression compared to pre-treatment (Figure 6B), none of patients with increased PHLPP expression. Here, PHLPP1 is linked to neoplasm.