RB1 and small cell lung carcinoma: In addition to TP53 and RB1, the genes with high mutation frequencies also detected in the previous SCLC studies, including LRP1B (44.00%), SPTA1 (26.00%), FAT1(20%), ARID1A (14%), CREBBP (14.00%), ROS1 (12.00%), and PTPRT (10.00%) (7, 10).