BRD4 and osteosarcoma: To exploring if BRD4 directly regulates GP130 expression through SEs, we first analyzed the distribution of H3K27Ac in the promoter region of GP130 in multiple cancer cell lines, including breast cancer (MCF-7), colon cancer (HCT116), Ewing sarcoma (A673), and osteosarcoma (SJSA1) et al.