IDH1 and central nervous system cancer: Also, using SB transposon system, we have developed: a DIPG murine tumor model of mACVR1-G328V by injecting plasmids encoding for NRASG12V, shp53, and mACVR1-G328V (66); a mIDH1 murine tumor model by injecting plasmids encoding for NRASG12V, shp53, shATRX and IDH1-R132H (44); and a H3.3-G34R murine high grade glioma model by injecting plasmids encoding for NRASG12V, shp53, shATRX and H3.3-G34R (67, 150).