SPP1 and central nervous system cancer: This strategy has been related to the overexpression of Spp1 (secreted phosphoprotein 1 or osteopontin) and Mgfe8 (milk fat globule-EGF factor 8 or lactadherin) on glioma cells and human glioblastoma tissue, which prompt M2 reprogramming of MG as a result of integrin signaling activation.