FYN and central nervous system cancer: To investigate the translational implications of targeting Fyn in glioma, we propose the use of glioma pre-clinical models to test the efficacy of nanoparticles loaded with small interfering RNA (siRNA) against Fyn. This strategy has the advantage of being systemically administrated, since nanoparticles have the ability to cross the brain-barrier and deliver their cargo directly into brain tumors (276, 277).