Other combinational therapy approach inhibiting the Neuroglial-2/Chondroitin sulfate proteoglycan-4 (NG2/CSPG4) axes using the antibody mAb9.2.27 together with activated NK cells in preclinical animal models of gliomas decreased tumor growth, by increasing recruitment of CCR2low MDM to the TME and by amplifying ED1 and MHCII expression on MG (218). The gene discussed is CSPG4; the disease is central nervous system cancer.